International Journal of Advances in Medical Biotechnology - IJAMB <p><strong>International Journal of Advances in Medical Biotechnology (IJAMB)</strong> is a peer-reviewed open access journal which provides a forum for discussion and dissemination of studies in Medical Sciences and Biotechnology fields. As a scientific publisher, IJAMB will focus on the dissemination of Original Papers, Reviews, Mini-reviews, Perspectives, Emerging Technologies and Spotlights relating scientific discoveries and inventions. The submitted papers should indicate the novelty and significant advances to the current state of knowledge and understanding of the proposed topic.</p><p>In this context, the IJAMB emerged as a means of sharing new knowledge oriented towards to the future which is related to the most relevant advances on Medical Sciences and Biotechnology fields. Therefore, the topics of interest to the current journal include: Regenerative Medicine; Biomembranes and Biopolimers; Slow delivery systems of drugs; Medical devices; Medical chemistry organic and inorganic; 3D structures; Growth factors; Tissue Engineering; Electronic technologies for health applications and papers focusing on biological, physiological and pharmacological modelling molecules.</p><p>As editorial guidance, the journal policy is based on the best practices of Brazilian and international scientific journals. Thus, the evaluation process adopted by the Journal is to publish peer-reviewed research which guarantees the confidentiality of authors and reviewers.</p><p>The Editorial Board is committed to build up a journal with international recognition and adequate indexation based on international and national data. We consider to analize content articles as commissioned, but the Journal is also open to welcome new ideas. Please contact the Editorial Office ( with your proposal; once a proposal is accepted or commissioned, detailed format guidelines will be provided.</p> International Journal of Advances in Medical Biotechnology (IJAMB) en-US International Journal of Advances in Medical Biotechnology - IJAMB 2595-3931 <p>Papers may not be offered for publication elsewhere whilst under consideration by the <em>International Journal of Advances in Medical Biotechnology - IJAMB</em>. The corresponding author must obtain the consent of all co-authors to the submission of the paper. Papers accepted by the Journal for publication may not be published elsewhere without the permission of the JOURNAL and acknowledgement of the original source of the publication.</p> Fibrous PCL scaffolds as tissue substitutes Luciana Pastena Giorno Leonardo Ribeiro Rodrigues Arnaldo Rodrigues Santos Junior Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB 2020-03-01 2020-03-01 3 1 10.25061/ijamb.v3i1.64 Synthesis and Characterization of S-IPN Hydrogels of Chitosan/PVA/PNIPAm to be Used in the Design of Nucleus Pulposus Prosthesis <span lang="EN-US">Hydrogels (HG) have been widely used in biomedical applications due to their high-water content which improves their biocompatibility with living tissue. In this study, Chitosan (CS) hydrogels cross-linked with Genipin and semi interpenetrated network (S-IPN) with PVA/PNIPAm were prepared to be used in the design of nucleus pulposus (NP) prosthesis. Chemical structure, morphology, swelling ratio (SR), mechanical properties and cytotoxicity were evaluated through a variation of the Genipin percentage and CS/PVA/PNIPAm proportions. Those experiments were carried out through Fourier-Transform Infrared Spectroscopy, Scanning Electron Microscopy, swelling studies, dynamic rheology, and hemocompatibility tests. The results showed that regardless of the Genipin percentage or polymers proportions, all HGs had interconnective porous structure. What did change microstructurally, was the pore size, its size distribution and the wall thickness. Firstly, an increment in the Genipin percentage and in the CS proportion concluded in an augmentation of the pore size. Secondly, an augmentation in the PVA proportion ended up producing smaller pores, with larger wall thickness and more homogeneous pore size distribution. The variation in PNIPAm proportion didn´t influence the morphology, but did have an impact on the SR and storage modulus (G´) augmenting in both cases as the PNIPAm proportion. The swelling ratio turned out to be related to the pore morphology; as smaller the pore size, smaller the SR. Likewise, the storage modulus rose insofar the SR diminished. In these S-IPN HGs, G´ varied between 77 Pa and 27000 Pa, values below and above G´ reported for human NP. Also, ? varied between 1.4° and 13.17° while the ? reported for NP is 23°-31°. Finally, the hemocompatibility tests did not show cellular lysis for any formulation. These outcomes demonstrated that from the rheological and hemocompatibility point of view, this kind of as semi interpenetrated networks (S-IPNs) HGs can be tailored to attain the NP´s properties</span> Marcos Antonio Sabino Reinaldo Andres Garcia Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB 2020-03-01 2020-03-01 3 1 2 15 10.25061/ijamb.v3i1.30 Production and characterization of membranes containing PCL and PVP obtained by simultaneous and blends electrospinning Ana Lorena Brito Soares João de Deus Pereira de Moraes Segundo Marcos Akira D'Ávila Fábia Karine Andrade Rodrigo Silveira Vieira Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB 2020-03-01 2020-03-01 3 1 16 22 10.25061/ijamb.v3i1.62