International Journal of Advances in Medical Biotechnology - IJAMB 2020-12-04T12:09:41-02:00 Hernane Barud Open Journal Systems <p><strong>International Journal of Advances in Medical Biotechnology (IJAMB)</strong> is a peer-reviewed open access journal which provides a forum for discussion and dissemination of studies in Medical Sciences and Biotechnology fields. As a scientific publisher, IJAMB will focus on the dissemination of Original Papers, Reviews, Mini-reviews, Perspectives, Emerging Technologies and Spotlights relating scientific discoveries and inventions. The submitted papers should indicate the novelty and significant advances to the current state of knowledge and understanding of the proposed topic.</p><p>In this context, the IJAMB emerged as a means of sharing new knowledge oriented towards to the future which is related to the most relevant advances on Medical Sciences and Biotechnology fields. Therefore, the topics of interest to the current journal include: Regenerative Medicine; Biomembranes and Biopolimers; Slow delivery systems of drugs; Medical devices; Medical chemistry organic and inorganic; 3D structures; Growth factors; Tissue Engineering; Electronic technologies for health applications and papers focusing on biological, physiological and pharmacological modelling molecules.</p><p>As editorial guidance, the journal policy is based on the best practices of Brazilian and international scientific journals. Thus, the evaluation process adopted by the Journal is to publish peer-reviewed research which guarantees the confidentiality of authors and reviewers.</p><p>The Editorial Board is committed to build up a journal with international recognition and adequate indexation based on international and national data. We consider to analize content articles as commissioned, but the Journal is also open to welcome new ideas. Please contact the Editorial Office ( with your proposal; once a proposal is accepted or commissioned, detailed format guidelines will be provided.</p> Fibrous PCL scaffolds as tissue substitutes 2020-10-20T10:44:16-03:00 Luciana Pastena Giorno Leonardo Ribeiro Rodrigues Arnaldo Rodrigues Santos Junior 2020-01-03T00:00:00-02:00 Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB Finite element analysis of temporomandibular Joint: detachment of the lateral pterygoid muscle 2020-09-07T08:38:23-03:00 Anita G. Mazzocco André Luiz Jardini Elifas Levy Nunes Rubens Maciel Filho <p><em>In biomedical engineering field, Temporomandibular joint (TMJ) is considered as a bi-component joint composed by fossa and condyle. It is considered the most active human joint and it performs daily activities such as speaking and chewing. Due to cyclic loading, TMJ disorders impair TMJ function so that it is necessary to replace the natural joint with an alloplastic prosthesis TMJ orthopedic prosthesis are made of metal alloys and ultra high molecular weight polymers. According to the literature, TMJ replacement surgery is commonly performed worldwide achieving good outcomes. However clinical outcomes point out that TMJ prosthesis present reduced joint kinematics with a limited translational mobility compared to natural joint. In case of unilateral TMJ replacement, this result generates a unilateral hipomobility and a contralateral overload. According to previous studies, this is caused by lateral pterygoid muscle detachment during condylectomy of replacement surgery. To investigate this phenomenon, this study use computational simulation with Ansys software. Finite element analysis is performed with the aim of evaluating effect of unilateral and bilateral pterygoid muscle detachment on mechanical behaviour of a natural human mandible subjected to molar and incisal bite.</em></p> 2020-01-03T00:00:00-02:00 Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB Abstracts of the1st International Digital Congress on 3D Biofabrication and Bioprinting (3DBB) 2020-12-04T12:09:41-02:00 Several authors <p>The <strong>1st International Digital Congress on 3D Biofabrication and Bioprinting (3DBB)</strong> took place on <strong>from 26 to 28th August 2020</strong>, in the city of Araraquara - São Paulo, Brazil.</p> 2020-01-03T00:00:00-02:00 Copyright (c) 2020 Cell viability evaluation of vero cells viability cultured on different chitosan films: development of functional biodressings possibilities 2020-12-02T18:17:04-02:00 Victor Campana Leite Warley Wagner Pereira Filho Enio Nazaré de Oliveira Junior Daniela Fabrino <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Os biomateriais utilizados na medicina regenerativa devem ter biocompatibilidade e ser atóxicos, pois são utilizados em contato com tecidos vivos para reparo ou reposição. </span><span style="vertical-align: inherit;">Portanto, eles devem fornecer um microambiente adequado para </span></span><em><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">ex vivo</span></span></em><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">cultura de células. </span><span style="vertical-align: inherit;">A quitosana é um biomaterial muito utilizado em pesquisas de cultura de células por ser atóxico, biocompatível, biodegradável, apresentar alta hidrofilicidade e apresentar importantes características antibacterianas. </span><span style="vertical-align: inherit;">Este trabalho estudou a interação de células VERO com filmes de quitosana produzidos com diferentes agentes de reticulação, avaliando a viabilidade e morfologia celular. </span><span style="vertical-align: inherit;">Os ensaios foram seguidos durante 96 horas para análise da proliferação celular, viabilidade e morfologia. </span><span style="vertical-align: inherit;">As células apresentaram desenvolvimentos distintos nos diferentes filmes, sendo o filme com ácido acético o menos adequado para cultivo apresentando viabilidade celular de 58%, por outro lado, filmes feitos a partir de soluções de quitosana com ácido lático ou cítrico tiveram viabilidade celular em torno de 70% . </span><span style="vertical-align: inherit;">Portanto, filmes de quitosana podem ser explorados como biomateriais para a produção de biodressing,</span></span></p> 2020-01-03T00:00:00-02:00 Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB Synthesis and Characterization of S-IPN Hydrogels of Chitosan/PVA/PNIPAm to be Used in the Design of Nucleus Pulposus Prosthesis 2019-10-07T19:36:57-03:00 Marcos Antonio Sabino Reinaldo Andres Garcia <span lang="EN-US">Hydrogels (HG) have been widely used in biomedical applications due to their high-water content which improves their biocompatibility with living tissue. In this study, Chitosan (CS) hydrogels cross-linked with Genipin and semi interpenetrated network (S-IPN) with PVA/PNIPAm were prepared to be used in the design of nucleus pulposus (NP) prosthesis. Chemical structure, morphology, swelling ratio (SR), mechanical properties and cytotoxicity were evaluated through a variation of the Genipin percentage and CS/PVA/PNIPAm proportions. Those experiments were carried out through Fourier-Transform Infrared Spectroscopy, Scanning Electron Microscopy, swelling studies, dynamic rheology, and hemocompatibility tests. The results showed that regardless of the Genipin percentage or polymers proportions, all HGs had interconnective porous structure. What did change microstructurally, was the pore size, its size distribution and the wall thickness. Firstly, an increment in the Genipin percentage and in the CS proportion concluded in an augmentation of the pore size. Secondly, an augmentation in the PVA proportion ended up producing smaller pores, with larger wall thickness and more homogeneous pore size distribution. The variation in PNIPAm proportion didn´t influence the morphology, but did have an impact on the SR and storage modulus (G´) augmenting in both cases as the PNIPAm proportion. The swelling ratio turned out to be related to the pore morphology; as smaller the pore size, smaller the SR. Likewise, the storage modulus rose insofar the SR diminished. In these S-IPN HGs, G´ varied between 77 Pa and 27000 Pa, values below and above G´ reported for human NP. Also, ? varied between 1.4° and 13.17° while the ? reported for NP is 23°-31°. Finally, the hemocompatibility tests did not show cellular lysis for any formulation. These outcomes demonstrated that from the rheological and hemocompatibility point of view, this kind of as semi interpenetrated networks (S-IPNs) HGs can be tailored to attain the NP´s properties</span> 2020-01-03T00:00:00-02:00 Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB Production and characterization of membranes containing PCL and PVP obtained by simultaneous and blends electrospinning 2020-09-25T20:28:20-03:00 Ana Lorena Brito Soares João de Deus Pereira de Moraes Segundo Marcos Akira D'Ávila Fábia Karine Andrade Rodrigo Silveira Vieira 2020-01-03T00:00:00-02:00 Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB Industrial Revolution 4.0 and the 3D printing in Biotechnology of tissue regeneration 2020-12-03T16:40:10-02:00 Lucas Noboru Fatori Trevizan Mayté Paredes Zaldivar Antônio Carlos Massabni <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Quando retratada para a sociedade atual, a indústria é considerada parte integrante da sociedade economicamente responsável pelo desenvolvimento e produção de bens de consumo. </span><span style="vertical-align: inherit;">Os processos de revolução industrial foram marcados pelas fases de aperfeiçoamento e avanços tecnológicos (1ª Revolução Industrial), o uso da energia elétrica (2ª Revolução Industrial) e a disseminação da digitalização da tecnologia (3ª Revolução Industrial). </span><span style="vertical-align: inherit;">Além disso, hoje em dia tais desenvolvimentos podem ser associados ao uso da internet e à automação de processos por inteligência artificial, chegando assim à 4ª Revolução Industrial. </span><span style="vertical-align: inherit;">O conceito da Indústria 4.0 está diretamente ligado ao conceito de tecidos inteligentes, a partir de fatores como inovação, </span><span style="vertical-align: inherit;">o que permite que as empresas tenham modelos de produção complexos, incluindo principalmente caráter sustentável e biotecnologias aplicadas. </span><span style="vertical-align: inherit;">Além disso, tanto a 4ª Revolução Industrial quanto a biotecnologia podem ser correlacionadas em termos de bioimpressão 3D. </span><span style="vertical-align: inherit;">Assim, o trabalho mostra um breve histórico das impressoras 3D e seu potencial em aplicações na área de engenharia de tecidos. </span><span style="vertical-align: inherit;">Revela a necessidade de multidisciplinaridade e de profissionais cada vez mais qualificados diante da nova fase de evolução socioindustrial.</span></span></p> 2020-01-03T00:00:00-02:00 Copyright (c) 2020 International Journal of Advances in Medical Biotechnology - IJAMB