Productionof poly(L-CO-D,L LacticAcid) porous fibers by electrospinning

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Nayara Maysa da Silva Carvalho
Bárbara E. Ciocca
Rubens Maciel Filho
Marcele Fonseca Passos
Maria Regina Wolf Maciel
Rogerio Furlan

Abstract

The production of porous scaffolds has been widely investigated by the scientific community due to its suitability for tissue engineering. Among techniques that allow the fabrication of porous materials, electrospinning is appealing for being robust and versatile. This research investigated the pore formation in poly (L-co-D,L lactic acid) fibers obtained by conventional electrospinning and the influence of chloroform as a single solvent on fiber morphology. Random and highly porous fibers with a mean diameter of 2.373 ± 0.564 µm were collected. Chloroform affects the fiber morphology, mainly for its fast evaporation and low density of charges. The solvent on the surface evaporates quickly, and the low stretch of the jet does not help the polymer to reorganize over the length of the fiber, forming pores. In conclusion, the low dielectric constant and boiling point of chloroform induce pores formation along the PLDLA fibers.


 

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How to Cite
Carvalho, N. M. da S., Ciocca, B. E., Maciel Filho, R., Passos, M. F., Wolf Maciel, M. R., & Furlan, R. (2021). Productionof poly(L-CO-D,L LacticAcid) porous fibers by electrospinning. International Journal of Advances in Medical Biotechnology - IJAMB, 3(2). https://doi.org/10.25061/ijamb.v3i2.61
Section
Research Articles
Author Biographies

Nayara Maysa da Silva Carvalho, University of Campinas, Campinas, Brazil

School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil;
National Institute of Biofabrication, School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, Brazil

Bárbara E. Ciocca, University of Campinas

School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil;

National Institute of Biofabrication, School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, Brazil

Rubens Maciel Filho, University of Campinas, Campinas, Brazil

School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, Brazil;
National Institute of Biofabrication, School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, Brazil

Marcele Fonseca Passos, University of Pará, Belém, Brazil

National Institute of Biofabrication, School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, Brazil;

School of Biotechnology, Biological Sciences Institute, University of Pará (UFPA), Belém, Brazil;

Maria Regina Wolf Maciel, University of Campinas, Campinas, Brazil

School of Chemical Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil

Rogerio Furlan, University of Puerto Rico at Humacao, Humacao, Puerto Rico, US

Department of Physics and Electronics, University of Puerto Rico at Humacao (UPRH), Puerto Rico, USA.