Tissue engineering of different cartilage types: a review of different approaches and recent advances

Karim Boumediene, Mira Hammad, Justin Dugué, Alexis Veyssière, Catherine Baugé

Abstract


Cartilage is a connective tissue that serves as a structural support for maintaining the shape for specific appendices (nose, ear) and also helps for shock absorption when present in joints. Different types of cartilage coexist in the body: hyaline, elastic and fibrocartilage. Due to their different embryologic origin, they produce distinct extracellular matrix and therefore have specific functions according to their location. Cartilage is frequently subjected to many different lesions. Those include traumatic, metabolic and congenital forms, concerning all regions where this tissue is present: joints, head and neck area, intervertebral disks, etc. Increasing number of cancers also affects cartilage; especially in ear, nose and trachea. Unfortunately, this tissue has a poor regeneration ability. Few therapeutic options exist for cartilaginous lesions and most of them concern articular cartilage. They include micro fracture, autologous chondrocytes implantation, mosaicplasty, allograft and prosthesis. Ear and trachea are also targeted for reconstruction with lesser extent. Therefore, cartilage engineering highly addresses increasing number of pathologies associated to this tissue. In the last two decades, several trials were investigated using both progenitor cells and scaffolds. Even bone marrow derived stem cells were widely used and served as gold standard. Many progenitors from different areas are investigated for their capacity of chondrogenesis. On the other hand, biomaterials, natural and synthetic, are used to induce a 3D environment that allows proper growth and differentiation toward cartilage formation. Their characteristics depend on the location of the expected graft where porosity, biodegradability, ability to support strength and large scale use are the key points. Favorable environments are also needed to achieve appropriate chondrogenesis, including biochemical or mechanical stimuli and low oxygen tension. Bioprinting showed also encouraging outcomes in cartilage reconstruction with the investigation of several scaffolds.


Keywords


Cartilage;Tissue engineering; Pathophysiology, Therapy.

Full Text:

PDF

References


Agrawal P, Pramanik K. Enhanced chondrogenic differentiation of human mesenchymal stem cells in silk fibroin/chitosan/glycosaminoglycan scaffolds under dynamic culture condition. Differentiation. 2019 Sep 19;110:36-48

Anthwal N, Thompson H. The development of the mammalian outer and middle ear. J Anat. 2016 Feb;228(2):217-32. doi: 10.1111/joa.12344. Epub 2015 Jul 30. Review.

Bae SW, Lee KW, Park JH, Lee J, Jung CR, Yu J, Kim HY, Kim DH. 3D Bioprinted Artificial Trachea with Epithelial Cells and Chondrogenic-Differentiated Bone Marrow-Derived Mesenchymal Stem Cells. Int J Mol Sci. 2018 May 31;19(6). pii: E1624. doi: 10.3390/ijms19061624

Baugé C, Boumédiene K. Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments. Stem Cells Int. 2015;2015:438026. doi: 10.1155/2015/438026. Epub 2015 Jul 9. Review.

Ciuffreda MC, Malpasso G, Musarò P, Turco V, Gnecchi M. Protocols for in vitro Differentiation of Human Mesenchymal Stem Cells into Osteogenic, Chondrogenic and Adipogenic Lineages.. Methods Mol Biol. (2016). Methods Mol Biol. 2016;1416:149-58. doi: 10.1007/978-1-4939-3584-0_8.

Decker RS. Articular cartilage and joint development from embryogenesis to adulthood. Semin Cell Dev Biol. 2017 Feb;62:50-56. doi: 10.1016/j.semcdb.2016.10.005. Epub 2016 Oct 20. Review.

Di Gesù R, Acharya AP, Jacobs I, Gottardi R. 3D printing for tissue engineering in otolaryngology. Connect Tissue Res. 2019

Duval E, Baugé C, Andriamanalijaona R, Bénateau H, Leclercq S, Dutoit S, Poulain L, Galéra P, Boumédiene K. Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering. Biomaterials. 2012 Sep;33(26):6042-51. doi: 10.1016/j.biomaterials. 2012.04.061. Epub 2012 Jun 6.

Duval E, Bouyoucef M, Leclercq S, Baugé C, Boumédiene K. Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes. IUBMB Life. 2016 Sep;68(9):756-63. doi: 10.1002/iub.1539. Epub 2016 Aug 13.4

Gaut C, Sugaya K. Critical review on the physical and mechanical factors involved in tissue engineering of cartilage. Regen Med. 2015;10(5):665-79. Epub 2015 May 22. Review.

Glatt V, Evans CH, Stoddart MJ Regenerative rehabilitation: The role of mechanotransduction in orthopaedic regenerative medicine.J Orthop Res. 2019 Jun;37(6):1263-1269. doi: 10.1002/jor.24205. Epub 2019 Jan 16. Review.

Jessop, ZM Javed M, Otto IA, Combellack EJ, Morgan S, Breugem CC, Archer CW, Khan IM, Lineaweaver WC, Kon M, Malda J, Whitaker IS. Combining regenerative medicine strategies to provide durable reconstructive options: auricular cartilage tissue engineering Stem Cell research and therapy, 2016 Jan 28;7:19. doi: 10.1186/s13287-015-0273-0

Korkusuz P, Kose S, Kopru CZ. Biomaterial and Stem Cell Interactions: Histological Biocompatibility. Curr Stem Cell Res Ther. 2016;11(6):475-486. Review.

Kunisaki C, Makino H, Takagawa R, Yamamoto N, Nagano Y, Fujii S, Kosaka T, Ono HA, Otsuka Y, Akiyama H, Ichikawa Y, Shimada H. 2007,) Surgical outcomes in esophageal cancer patients with tumor recurrence after curative esophagectomy. J Gastrointest Surg. 2008 May;12(5):802-10. Epub 2007 Oct 20.

Mazor M, Lespessailles E, Coursier R, Daniellou R, Best TM, Toumi H. Mesenchymal stem-cell potential in cartilage repair: an update. J Cell Mol Med. 2014 Dec;18(12):2340-50. doi: 10.1111/jcmm.12378. Epub 2014 Oct 29. Review

Pourbashir S, Shahrousvand M, Ghaffari M. Preparation and characterization of semi-IPNs of polycaprolactone/poly (acrylic acid)/cellulosic nanowhisker as artificial articular cartilage. Int J Biol Macromol. 2019 Oct 5. pii: S0141-8130(19)33740-7.

Suzuki J, Osumi N. Neural crest and placode contributions to olfactory development. Curr Top Dev Biol. 2015;111:351-74. doi: 10.1016/bs.ctdb.2014.11.010. Epub 2015 Jan 20. Review

Takebe T, Kobayashi S, Kan H, Suzuki H, Yabuki Y, Mizuno M, Adegawa T, Yoshioka T, Tanaka J, Maegawa J, Taniguchi H. Human elastic cartilage engineering from cartilage progenitor cells using rotating wall vessel bioreactor. Transplant Proc. 2012 May;44(4):1158-61. doi: 10.1016/ j.transproceed.2012.03.038

Watson D, Hecht A. Repair of Auricular Defects. Facial Plast Surg Clin North Am. 2017.

Zamborsky R, Kilian M, Jacko P, Bernadic M, Hudak R. Perspectives of 3D printing technology in orthopaedic surgery. Bratisl Lek Listy. 2019;120(7):498-504.




DOI: https://doi.org/10.25061/2595-3931/IJAMB/2019.v2i1.33

Refbacks

  • There are currently no refbacks.


Rua Carlos Gomes, 1217 | Araraquara-SP  | ZIP 14801-340 -  e-ISSN:  2595-3931