Approaches to the development of 3d bioprinted skin models: the case of natura cosmetics

Ana Millás, Juliana Lago, Luciana Vasquez-Pinto, Pedro Massaguer, Silvya Stuchi Maria-Engler

Abstract


Estamos perto de alcançar a produção de uma pele funcional biomimética e esse avanço se deve principalmente à demanda que não se limita ao campo da medicina regenerativa, à necessidade de transplante desse órgão devido ao envelhecimento da população, mas pela ética. razões relacionadas aos testes de segurança e eficácia de novas fórmulas em modelos animais pelas indústrias cosmética e farmacêutica. As limitações envolvidas nas abordagens tradicionais da cultura de células 2D e nas técnicas manuais para geração biomimética impulsionaram o uso de tecnologias inovadoras, como a bioimpressão 3D. Uma das principais vantagens da pele bioprimida é a autenticidade, escalabilidade e reprodutibilidade dos tecidos em comparação às construções convencionais, através do posicionamento preciso de vários tipos de células e da inclusão de anexos. Os modelos de peles bioprintadas servirão de plataforma para o desenvolvimento de novas formulações, testes de moléculas, simulação de doenças, bem como uma alternativa aos biocurativos de feridas crônicas e transplantes clínicos. Este artigo analisa as abordagens de última geração disponíveis para a bioimpressão de modelos de pele, discute o contexto da indústria cosmética na adoção desses modelos e apresenta as características do projeto em desenvolvimento na Natura Cosmetics.

 


Keywords


3D bioprinting; biofabrication; alternative methods; Natura Cosmetics; in vitro skin

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DOI: https://doi.org/10.25061/2595-3931/IJAMB/2019.v2i1.24

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